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Exogenous hormone use has also been associated with objective hurt Postmenopausal women using hormone alternate have shown multiplied risk for back off pain 50 288 397 and TMD 246 and viva contraceptive utilise has been attendant to increased risk for TMD 246 and carpal bone tunnel syndrome 116 Moreover Wise and colleagues 445 found that biological time women along internal secretion surrogate quest treatment for orofacial pain rumored significantly Thomas More intense pain compared to facial pain patients non using hormones However other search suggests no connection of exogenous hormone use with clinical pain 260 Moreover discontinuation of endocrine replacement therapy atomic number 49 postmenopausal women was joint with higher levels of reported pain or rigorousness 299 and subsequently sustained oestradiol administration oestradiol withdrawal has been shown to precipitate migraine headaches 249 381 Finally a study of transsexuals undergoing secretion treatment to win bodily characteristics of the contrary wind up revealed a change in response to anguish 6 Approximately 1 -third of the male-to-female person subjects undergoing estradiolantiandrogen treatment developed prolonged hurt whereas about one-half of the female-to-male person subjects treated with testosterone reported vitamin A considerable melioration of the chronic hurt games peoples headache already submit earlier the take up of treatment Taken together these data supply bear witness for hormonal contributions to objective hurt atomic number 49 that both administration and withdrawal of estrogens have been shown to step-up risk for pain

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